Bioactive Small Molecules
Cayman Chemical BelIzatInIb 25mg
An inhibitor of ALK and tropomyosin-related kinases A/B/C (IC50s = 0.7 and <3 nM, respectively)
Cayman Chemical ANTIBODY Bentazepam 1mg
An analytical reference standard categorized as a benzodiazepine; intended for research and forensic applications
Cayman Chemical ANTIBODY ClopyralId 100mg
An herbicide; selectively inhibits the growth of the broadleaf weed L. palustris over a panel of 17 New Zealand native non-broadleaf plant species when applied at 1.5 mg/L; does not inhibit growth of human pluripotent stem cells (IC50 = >100 μM) or decrease nuclear translocation of the transcription factor SOX17
Cayman Chemical CAY10740hydrochlorIde 5mg
An analog of GSK484; decreases the viability of 4T1 cells by 85 and 98% at 5 and 10 μM, respectively, which is more than five-fold as effective as GSK484
Cayman Chemical ANTIBODY A286982 25mg
An inhibitor that blocks the integrin-ligand interaction between LFA-1 and ICAM-1 (IC50 = 35 nM); inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC50 = 44 nM)
Cayman Chemical ANTIBODY ImazalIl 50mg
An imidazole fungicide that inhibits ergosterol biosynthesis; inhibits the growth of various fungi in vitro including P. italicum, A. niger, U. maydis, B. alii, and C. cucumerinum in a pH-dependent manner (MICs = 0.005-2 μg/ml at pH 7); inhibits S. cerevisiae, but not rat liver microsomal, CYPs (IC50s = 0.088 and 80 μM, respectively), as well as aromatase CYP19 from human placental microsomes (IC50 = 0.34 μM); activates the murine PXR in a concentration-dependent manner in a cell-based reporter assay; increases hepatic CYP3A11 and CYP2B10 mRNA levels in mice at 100 mg/kg; increases Ki-67-positive nuclei in liver sections and hepatic MCM2 mRNA levels, markers of cell proliferation, in mice when co-administered with the mCAR agonist TCPOBOP
Medchemexpress LLC BMS-986158 | 1800340-40-2 | 99.8% | 495.62 | 100 MG
BMS-986158 is a potent BET inhibitor effective in various cancer cell lines, with IC50s of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells. It functions by inhibiting the bromodomain (BRD) and extra-terminal domain (BET) family of proteins, disrupting chromatin remodeling and preventing the expression of growth-promoting genes. This ultimately leads to an inhibition of tumor cell growth. It is intended for research use only.
- Potent BET inhibitor
- Inhibits bromodomain (BRD) and extra-terminal domain (BET) family proteins
- Disrupts chromatin remodeling
- Prevents expression of growth-promoting genes
- Inhibits tumor cell growth
Medchemexpress LLC Pi3k/akt-in-2 | 2684412-41-5 | 98.1% | 651.45 | 5 MG
PI3K/AKT-IN-2 (Compound 12c) is identified as an inhibitor of PI3K and AKT. It has been shown to block epithelial-mesenchymal transition (EMT), induce apoptosis, and inhibit the polymerization of tubulin.
- It is a PI3K and AKT inhibitor.
- It blocks the epithelial-mesenchymal transition (EMT).
- It induces apoptosis.
- It inhibits the polymerization of tubulin.
- It demonstrates antiproliferative activity against various cell lines (H460, MCF-7, A549, HGC-27, 293 T, and GES-1 cells) with specific IC50 values.
- It suppresses the expressions/activities of matrix metalloprotease (MMP)-2 and vimentin, and up-regulates E-cadherin.
- It induces significant up-regulation of CDK1 proteins expression while down-regulating cyclin B1 and Cdc25C.
Cayman Chemical ANTIBODY RX-3117 1mg
A nucleoside derivative and an anticancer agent; cytotoxic to HCT116, MDA-MB-231, PANC-1, A549, and U251 cancer cells (IC50s = 0.39, 0.18, 0.62, 0.34, and 0.83 µM, respectively); induces DNA damage and apoptosis in A2780 cells at 1 and 10 µM; reduces mean tumor volume in HCT116, HT-29, Caki-1, MIA PaCa-2, and BxPC-3 mouse xenograft models from 50-500 mg/kg
Cayman Chemical ANTIBODY BPN14770 10mg
A PDE4D inhibitor; selectively inhibits dimeric PDE4DS129D and PDE4DS54D over wild-type dimeric PDE4D, dimeric PDE4DS133D, and monomeric PDE4D2 (IC50s = 7.8, 7.4, 1,018, 2,013, and 127 nM, respectively); enhances novel object discrimination in mice from 0.3-30 mg/kg; decreases hyperarousal and increases social interaction time, indicating anxiolytic-like activity, nesting, and marble-burying behavior in the Fmr1-/- mouse model of fragile X syndrome at 0.3 mg/kg
Cayman Chemical NG NG-dImethyl-L-ArgInIn 5mg
An endogenous NOS inhibitor; levels are increased in Dahl salt-sensitive rats fed a high-salt diet concomittant with an increase in blood pressure
Cayman Chemical ANTIBODY DFHBI 1T 5mg
A fluorescent probe for RNA; ex/em = 447/501 nm, respectively; fluoresces upon binding to RNA aptamers; has been used to image RNA in live cells
Selleck Chemical LLC Lexibulin (CYT997) S2195-5mg
Lexibulin (CYT997 SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines Phase 2
Selleck Chemical LLC Bafetinib S1369-25mg
Bafetinib is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5 8 nM/19 nM in cell-free assays does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit