Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,636 – 4,650 of 60,538 results

4,636

Cayman Chemical Asperphenamate, Purity: ≥95%, CAS: 63631-36-7, 5 mg

A fungal secondary metabolite; inhibits proliferation of T47D and MDA-MB-231 breast and HL-60 leukemia cancer cell lines (IC50s = 92.3, 96.5, and 97.9 μM, respectively); inhibits yeast α-glucosidase activity (IC50 = 8.3 μM)

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4,637

TARGETMOL CHEMICALS INC FUCOSTEROL 10MG

Also available in 1 mg 5 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Fucosterol is isolated from E. stolonifera with anti-diabetic anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPAR(alpha) and C/EBP(alpha) expression. purity: 99%

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4,638

Medchemexpress LLC (3S,9BR)-3-((1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one | 1643469-17-3 | 99.3% | 10MM 1ML

(3S,9BR)-3-((1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one | 1643469-17-3 | 99.3% | 10MM 1ML

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4,639

Medchemexpress LLC HY-103586 100mg Medchemexpress, GS-441524 CAS:1191237-69-0 Purity:>98%

Medchemexpress, HY-103586 100mg GS-441524 CAS:1191237-69-0 GS-441524, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC50 of 0.78 μM[2][3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,640

Cayman Chemical CPI-360, Purity: ≥98%, CAS: 1802175-06-9, 10 mg

A selective EZH2 inhibitor (IC50s = 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively); decreases cellular levels of H3K27me3 and H3K27me2 (EC50s = 56 and 65 nM, respectively), triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of NHL cell lines

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4,641

Cayman Chemical Amylose, CAS: 9005-82-7, 250 mg

A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins

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4,642

Medchemexpress LLC Disopyramide | 3737-09-5 | MFCD00057366 | 99.7% | 339.47 g/mol | C21H29N3O | 10MM 1ML

Disopyramide is a class IA antiarrhythmic agent used in research to investigate ventricular and atrial arrhythmias. It blocks fast inward sodium currents, prolongs cardiac action potential duration, and inhibits hERG-encoded potassium channels, making it useful for electrophysiology and pharmacology studies. Supplied for in vitro use with guidance for solvent preparation and storage.

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4,643

Enzo Life Sciences Microcystin-LW (25µg). CAS: 157622-02-1

Analog of microcystin-LR (ALX-350-012) with Trp substituted in place of Arg. Hydrophobic and believed to be more cell permeable than other microcystins. May prove useful in biochemical studies in intact cells. Microcystin-LW has a characteristically different absorption spectrum compared to other microcystins, making it a useful reference compound for HPLC analysis. The Trp confers an absorption maximum at 222nm, whereas most microcystins have a characteristic maximum at 239nm. Purity: ≥95% (HPLC). Solubility: Soluble in 100% methanol. Long Term Storage: -20°C.

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4,644

Cayman Chemical ANTIBODY SCH 900776 500ug

A functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM); interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells

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4,645

Cayman Chemical Liproxstatin-1, Purity: ≥95%, CAS: 950455-15-9, 5 mg

A ferroptosis inhibitor; inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in inducible Gpx4-/- MEFs at 50 nM; inhibits ferroptosis induced by the ferroptosis-inducing agents BSO, erastin, and (1S,3R)-RSL3 in a concentration-dependent manner in MEFs; inhibits cell death and lipid peroxidation induced by (1S,3R)-RSL3 in human renal proximal tubule epithelial cells; increases survival and decreases TUNEL+ kidney cells in inducible Gpx4-/- mice at 10 mg/kg; reduces tissue injury in a mouse model of hepatic ischemia/reperfusion injury; an antioxidant that inhibits autooxidation of lipids by trapping peroxyl radicals

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4,646

Medchemexpress LLC TC-G 1005 | 1415407-60-1 | 99.3% | 399.48 | 100 MG

TC-G 1005 is a potent, selective, and orally active agonist of the BA receptor Takeda G protein-coupled receptor 5 (TGR5), with EC50s of 0.72 nM for hTGR5 and 6.2 nM for mTGR5. It can reduce glucose levels in vivo.

Potent and selective TGR5 agonist.
Orally active.
Activates human and mouse TGR5.
Stimulates GLP-1 secretion.
Reduces blood glucose levels.

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4,647

Cayman Chemical MSC2530818, Purity: ≥98%, CAS: 1883423-59-3, 10 mg

A Cdk8 inhibitor (IC50 = 2.6 nM); selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit GSK3α (IC50 = 691 nM); inhibits STAT1 phosphorylation in SW620 colorectal cancer cells (IC50 = 8 nM); inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays); reduces tumor growth in a SW620 mouse xenograft model at 50 and 100 mg/kg

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4,648

Medchemexpress LLC S2101 | 1239262-36-2 | 99.7% | 311.76 | 1 ML

S2101 is a lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 0.99 μM, Ki of 0.61 μM, and Kinact/Ki of 4560 M/s. It exhibits lower inhibition activity toward MAO-B (Ki=17 μM, Kinact/Ki=18 M/s) and MAO-A (Ki=110 μM, Kinact/Ki=60 M/s). Treatment of HEK293T cells with S2101 leads to a dose-dependent increase in H3K4me2 levels, indicating LSD1 inactivation. It is approximately 50-fold stronger in LSD1 inhibition activity than 2-PCPA in human cells.

Potent and selective inhibition of LSD1
Lower inhibition activity toward MAO-B and MAO-A
Induces dose-dependent increase in H3K4me2 levels
Approximately 50-fold stronger LSD1 inhibition than 2-PCPA in human cells

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4,649

Medchemexpress LLC D-(-)-Lactic acid-13C | 2102426-04-8 | 99.9% | 91.07 | 50 MG

D-(-)-Lactic acid-13C ((R)-2-Hydroxypropionic acid-13C) is a 13C-labeled D-Lactic acid. It can be utilized as an internal standard and for studies involving metabolic tracing.

This compound can be used as a tracer.
It can serve as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.

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4,650

Medchemexpress LLC KP-457 | 1365803-52-6 | 99.18% | 480.55 | 10 MG

KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, demonstrating higher selectivity for ADAM17 than for other MMPs and ADAM10. It functions by blocking Zn2+ chelation of the catalytic domain of ADAM17.

Selective ADAM17 inhibitor
Blocks Zn2+ chelation of ADAM17 catalytic domain
Retains GPIbα expression on iPSC-derived platelets
Supports good hemostatic function in iPSC platelets

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Medchemexpress LLC (3S,9BR)-3-((1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one | 1643469-17-3 | 99.3% | 10MM 1ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-103586 100mg Medchemexpress, GS-441524 CAS:1191237-69-0 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Disopyramide | 3737-09-5 | MFCD00057366 | 99.7% | 339.47 g/mol | C21H29N3O | 10MM 1ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC TC-G 1005 | 1415407-60-1 | 99.3% | 399.48 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC S2101 | 1239262-36-2 | 99.7% | 311.76 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC D-(-)-Lactic acid-13C | 2102426-04-8 | 99.9% | 91.07 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC KP-457 | 1365803-52-6 | 99.18% | 480.55 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More